exquisite pain, agony, etc
I couldn't sleep for exquisite pain.
A cancer patient usually suffers exquisite pain.
It was immediately responded to by a light, airy, childish laugh, in which, with a thrill of the heart -- but he knew not whether of exquisite pain, or pleasure as acute -- he recognized the tones of little Pearl.
Each piece is unique, an exquisite painting of a real person, done on ivory.