(1) In white mice, intraperitoneal injections of mixture of procaine (70 mg/ kg/day) and tartar emetic for 14 days reduced the toxicity of tartar emetic, raising the LD_(50) of the latter from 35 to 45 mg/kg/day.
(4) In rabbits infected with Schistosoma japonicum, intravenous injections of mixture of procaine (10 mg/kg/day) and tartar emetic for 14 days could increase the therapeutic activities of tartar emetic. Injections of mere procaine showed no antibilharzial effcct.
(3) Procaine, sodium phenyl acetate, sodium α α'-dimercaptoadipate and sodium mercaptosuccinate did not decrease the therapeutic. activity of tartar emetic, and, moreover, procaine could significantly augment its therapeutic activity against schistosomiasis japonica.
