Conclusion R492X nonsense mutation of PINK1 gene was rare in Chinese sporadic patients with PD.
Nonsense termination in human cells may also be susceptible to suppression by antisense agents, providing a new approach to address numerous diseases caused by nonsense mutations.
Thus, it is possible to significantly suppress nonsense mutations within target genes using antisense PNAs.
Duchene's muscular dystrophy and cystic fibrosis are examples of hereditary diseases that result from nonsense mutations.
About 10 to 15 percent of all DBMD cases are caused by nonsense mutations in the dystrophin gene.
For example, the most well-described pathway is one that recognizes nonsense mutations that result in an RNA that makes a protein that is too short.
